All 3 targets are important to watch when the price hits them.
The first three targets are significant, and when the price breaks through them, next target will be Wolfe Waves pattern target. Each time the price reaches and breaks out of a target, it signifies increased buying power.
No stop-loss is necessary, as you can observe MACD divergences, even on small timeframes. This implies an impending bullish trend, although any movement before that point is possible.