Wall St opens lower ahead of Fed decision; AMD rises on outlook

U.S. stock indexes opened lower on Wednesday as investors cautiously awaited the Federal Reserve's decision on interest rates later in the day, while chipmaker Advanced Micro Devices climbed on an upbeat outlook.

The Dow Jones Industrial Average DJI fell 46.44 points, or 0.14%, at the open to 34,039.60. The S&P 500 SPX opened lower by 6.53 points, or 0.16%, at 4,070.07, while the Nasdaq Composite IXIC dropped 11.41 points, or 0.10%, to 11,573.14 at the opening bell.