GameStop, General Electric, Merck

Wall Street's main stock indexes were set to gain at open on Wednesday as chipmakers and growth stocks rebounded in light trading ahead of crucial economic data, commentary from the Federal Reserve's policymakers and a long holiday weekend.

At 9:04 ET, Dow e-minis (1YMc1) were up 0.42% at 39,846. S&P 500 e-minis ES1! were up 0.48% at 5,290.75, while Nasdaq 100 e-minis NQ1! were up 0.56% at 18,552.75.

The top two NYSE percentage gainers premarket (.PRPG.NQ):

** GCT Semiconductor Holding GGCTS, up 77.1%

** MariaDB plc MRDB, up 75.6%

The top three NYSE percentage losers premarket (.PRPL.NQ):

** Velo3D VLD, down 34.4%

** VirnetX Holding VHC, down 20.6%

** GameStop GME, down 15.5%

The top Nasdaq percentage loser premarket (.PRPL.O):

** Gamida Cell (GMDA.O), down 77.5%

** argenx SE ARGX: up 0.4% premarket

BUZZ - Plans to pursue efgartigimod development in SjD lift argenx shares

** Merck & Co MRK: up 4.6% premarket

BUZZ - Up as FDA approves therapy for rare lung condition

** Paysign Inc PAYS: up 12.4% premarket

BUZZ - Surges on strong revenue forecast

** GameStop Corp GME: down 15.5% premarket

BUZZ - Drops as competition, slow consumer spending weigh on Q4 revenue

** Forge Global Holdings Inc FRGE: down 11.3% premarket

BUZZ - Dips after bigger-than-expected Q4 loss

** Moderna Inc MRNA: up 2.6% premarket

BUZZ - Rises on $750 mln funding agreement with Blackstone Life Sciences

** Direct Digital Holdings Inc DRCT: down 47.6% premarket

BUZZ - Falls after results, outlook miss

** Kimberly-Clark Corp KMB: up 1.5% premarket

BUZZ - Gains on business reorganization

** General Electric Co GE: up 0.7% premarket

BUZZ - Wells Fargo upgrades PT on General Electric over cost cutting potential

** Novocure Ltd NVCR: up 17.8% premarket

BUZZ - Surges as cancer therapy succeeds in late-stage trial

** Altimmune Inc ALT: down 12.4% premarket

BUZZ - Falls on failure of hepatitis B treatment trial

** Bowman Consulting Group Ltd BWMN: down 13.2% premarket

BUZZ - Slides on pricing $50 mln stock offering