Pure Storage, Pfizer, Southern First Bancshares

U.S. stock indexes fell on Wednesday, as investors locked in profits after a strong 2023 and awaited the Federal Reserve's December meeting minutes that could offer hints on its interest rate path.

At 10:46 ET, the Dow Jones Industrial Average DJI was down 0.80% at 37,413.84. The S&P 500 SPX was down 0.80% at 4,704.77 and the Nasdaq Composite IXIC was down 1.03% at 14,614.38.

The top three S&P 500 (.PG.INX) percentage gainers:

** Eli Lilly , up 3%

** Marathon Petroleum , up 2.9%

** Arch Capital Group , up 2.5%

The top three S&P 500 (.PL.INX) percentage losers:

** Enphase Enrgy , down 8.8%

** Align Tech , down 6.9%

** Albemarle , down 6.7%

The top three NYSE (.PG.N) percentage gainers:

** TDCX , up 31.7%

** China Green Agriculture , up 16.8%

** Bright Health Group , up 16.6%

The top two NYSE (.PL.N) percentage losers:

** Banyan Acquisition , down 32.5%

** Altisource Asset Management , down 21.9%

The top three Nasdaq (.PG.O) percentage gainers:

** NexImmune , up 224.2%

** Sidus Space , up 65.4%

** Sigma Additive Solutions , up 46.2%

The top three Nasdaq (.PL.O) percentage losers:

** Esperion Therapeutics , down 27.1%

** TC BioPharm , down 22.8%

** Peraso , down 22.2%

** SoFi Technologies SOFI: down 14.0%

BUZZ - Falls as KBW turns bearish after stock's recent run

** Dyne Therapeutics DYN: up 10.6%

BUZZ - Jumps on positive data for muscular disorder drugs

** Agios Pharmaceuticals AGIO: up 3.4%

BUZZ - Rises as blood disorder drug meets late-stage study goals

** Regeneron Pharmaceuticals REGN: up 1.0%

BUZZ - Leerink sees increased sales for Regeneron's eye drug, raises PT - Reuters

** Coinbase Global COIN: down 4.5%

** Bitfarms BITF: down 4.9%

** Riot Platforms RIOT: down 5.7%

** Marathon Digital Holdings MARA: down 2.9%

BUZZ - Crypto stocks slide as bitcoin comes off 21-month high

** Merck & Co MRK: up 1.7%

BUZZ - Citi picks Merck as its preferred pharma stock

** ABVC BioPharma ABVC: up 53.3%

BUZZ - Up on receiving $460 mln worth shares under licensing deal

** Xponential Fitness XPOF: down 6.8%

BUZZ - Falls after Piper Sandler downgrades to 'neutral'

** Newmont Corp NEM: down 3.2%

** Barrick Gold Corp ABX: down 2.4%

** AngloGold Ashanti Ltd AU: down 2.0%

** Harmony Gold Mining Co Ltd HAR: down 2.3%

BUZZ - Gold miners slip on stronger dollar

** SentinelOne S: down 5.1%

BUZZ - To acquire PingSafe, shares drop

** Pure Storage PSTG: up 5.7%

BUZZ - Rises after inclusion in S&P mid-cap index, Stifel PT raise

** Pfizer PFE: up 0.3%

BUZZ - Up on Canada approval for bleeding disorder gene therapy

** Suncor Energy SU: up 4.4%

BUZZ - Rises after flagging second-highest output in Q4

** Southern First Bancshares SFST: up 3.3%

BUZZ - Rises after Piper Sandler upgrades to 'overweight'

** Sarepta Therapeutics SRPT: down 2.6%

BUZZ - Down after Dyne's drug trial for muscle disorder shows better result

The 11 major S&P 500 sectors: